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I am a Medical Oncologist with 18 years experience at Consultant level and specialise in the medical treatment of a range of cancers. I am the only provider of private Medical Oncology services in Gloucestershire. I trained in several London teaching Hospitals including the Royal Marsden, St Bartholomew's and Guy's Hospital and also undertook a research degree (PhD) at the Institute of Cancer Research, Royal Marsden Hospital, London. Research continues to be an integral part of my practice in order to drive new developments in care for my patients as well as providing them with the latest and most cutting-edge treatments.
I am a leader in the introduction of targeted biological therapies and Immunotherapy in a range of solid tumours in our service. I am also leading on the introduction of molecular profiling to introduce new treatments based on the genetic signature rather than site of origin.
Areas of interest
Investigation and treatment of Cancer of Unknown primary, Neuroendocrine tumours; Lung cancer; Malignant Mesothelioma; Malignant melanoma; Colorectal (bowel) cancer; Kidney (renal) cancer; Testicular cancer;
Current NHS consultant posts held
Consultant Medical Oncologist
Gloucestershire Oncology Centre
Cheltenham General Hospital
Predictors of response to treatment (Precision medicine)
Supportive care of patients undergoing anti-cancer therapy.
Patient decision aids in Cancer of Unknown Primary
3. ASCO Merit Award at the May 1999 Annual meeting in Atlanta, Georgia, for a poster discussion presentation entitled “Genomic Study Of Patients With Advanced Colorectal Cancer Treated With Raltitrexed (‘Tomudex’)”.
Chief Medical Officer’s Award for services to Commercial Research 2015.
Abbvie Pharmaceuticals Gold Star Award for recruitment into Lung Cancer Studies 2015.
Shortlisted for a Gloucestershire Hospitals NHS Foundation Trust Staff Award for Services to Research 2017.
(Additional) Languages spoken
- Maltese - Native or bilingual
- Italian - Conversational
FARRUGIA DC, NORMAN AR, et al. Unknown Primary Carcinoma: Randomised Studies are needed to identify optimal Treatments and their Benefits. Eur J of Cancer. 1996; 32A: 2256-2261.
D C FARRUGIA, A R NORMAN AND D CUNNINGHAM. Single Agent Infusional 5-FU is not Effective Second Line Therapy after Tomudex in Advanced Colorectal Cancer. Eur J of Cancer. 1998; 34(7): 987-991..
FORD, H E, MITCHELL F, CUNNINGHAM D, FARRUGIA D C et al. "Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331." Clin Cancer Res 2002; 8(1): 103-9.
FARRUGIA D, FORD H, et al. Thymidylate Synthase Expression in Advanced Colorectal Cancer Predicts for Response to Raltitrexed. Clin Cancer Res 2003; 9: 792-801.
GUGLANI S, FARRUGIA D, et al. Reversible Life-Threatening Encephalopathy In The Absence Of Hepatic Failure Following Conventional Doses Of Docetaxel. Clin Oncol (R Coll Radiol). 2003; 15(3): 160-1.
MEDLEY, L., A. N. MOREL, D FARRUGIA et al. (2011). "Phase II study of single agent capecitabine in the treatment of metastatic non-pancreatic neuroendocrine tumours." Br J Cancer 104(7): 1067-70.
PAYNE, M. J., K. ARGYROPOULOU, LORIGAN, P., MCALEER, J. J., FARRUGIA, D., et al. (2013). "Phase II Pilot Study of Intravenous High-Dose Interferon With or Without Maintenance Treatment in Melanoma at High Risk of Recurrence." J Clin Oncol. Dec 16.
DECATRIS, M. P., FARRUGIA, D. et al. (2016). "Clinician Perspective on Molecular Profiling of Non-Small-Cell Lung Cancer." J Clin Oncol 34(8): 884-886.
T IVESON, RS KERR, et al. (2018). '3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial', Lancet Oncol, 19: 562-78.
CORRIE P.G, MARSHALL A, et al. on behalf of the AVAST-M Investigators. (2018). Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial. Ann Oncol, 29: 1843-52.
PETER VINK, IGNACIO DELGADO MIGNORANCE et al. “Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Vaccine in Adults with Solid Tumors, Vaccinated Before or During Chemotherapy: Randomized Trial”. Accepted for publication in Cancer, October 2018.
Courses offered to GPs
Update lectures to GPs on Cancer of Unknown Primary, Skin cancer, Kidney cancer, Lung Cancer, neuroendocrine tumours.
- MD University of Malta 1987
- PhD University of London 1998
- FRCP Royal College of Physicians, London 2004
- CCST Medical Oncology JCHMT, London 2000
Reference number 3641426
Affiliations / memberships
1. American Association of Clinical Oncology (ASCO)
2. Association of Cancer Physicians (ACP), UK
3. European Society of Medical Oncology (ESMO)
4. British Thoracic Oncology Group (BTOG)
5. EORTC melanoma group
6. UK Melanoma FOCUS Group
7. UK Neuroendocrine Tumour Study Group (UKINETS)
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.
In the event of an urgent query following treatment, Bupa members should use the following contact details
Oncology Helpline, Cheltenham General Hospital.