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Last updated: 12 Nov 2020
- General cardiology
- Interventional cardiology
Dr Chai offers a unique spectrum of comprehensive cardiac care from preventive cardiology (especially lipid management), to interventional cardiology, as well as cardiac rehabilitation. As an elected Rolleston Scholar of St Johns College, University of Cambridge, Dr Chai qualified in clinical medicine from Cambridge with first class honours. He subsequently completed his post-graduate general medical training in St Bartholomews, London Chest, and the Royal London Hospitals, before embarking on Cardiology specialist training in St Georges Hospital and King's College Hospital in London. With the prestigious Medical Research Council Clinical Research Fellowship to pursue his doctoral research, Dr Chai completed his PhD / DPhil in Cardiovascular Medicine at the University of Oxford.
His research focused on the translational aspect using a novel clinically useful non-invasive MRI technique in characterising atherosclerotic plaque especially lipid composition, which was then correlated to the functional heterogeneity of plaque inflammatory cells using gene expression microarray technology. This novel platform of plaque characterisation showed early promise in facilitating future efforts in patient stratification for more individualised treatment against atherosclerotic disease.
His research has won many awards including Young Investigator Award at the European Atherosclerosis Society, Finalist award for the American Heart Association Melvin Judkins Young Clinical Investigators, and more recently, the Presidents Prize from the Royal Society of Medicine.
Dr Chai joined Wexham Park Hospital, part of Frimley Health NHS Foundation Trust, after completion of a further post-CCT complex coronary interventional fellowship in Bournemouth. He is currently the Clinical Lead in the Chest Pain Service and the Rapid Access Suspected Angina Clinic. He also chairs the weekly Cardiac CT MDT with his radiology colleagues. He successfully introduced new technology platform into Wexham Park Cardiac Catheter Laboratory - including state-of-the-art intracoronary imaging technique with co-registered Optical Coherence Tomography, and advanced calcium modification techniques using rotational atherectomy and shockwave intravascular lithotripsy, as well as development of a new complex interventional programme at Wexham Park Hospital.
In his spare time, he is an avid wedding and portrait photographer.
Areas of interest
Preventive cardiology, coronary artery disease; percutaneous coronary intervention; arrhythmia; hypertension; lipid management; valvular heart disease; heart failure; echocardiography; cardiac CT; cardiac rehabilitation
- Neha Gurung
- Wexham Park Hospital Cardiology Department Wexham Street Wexham Slough SL2 4HL
- 01753 415889
- 07537 181168
Current NHS consultant posts held
Consultant Cardiologist, Wexham Park Hospital, Wexham Street, Slough, SL2 4HL
Cardiovascular MRI; Cardiac CT; vascular and plaque biology
Wedding and portrait photography
President's Prize from Royal Society of Medicine (2016); Finalist award for American Heart Association Melvin Judkins Young Clinical Investigators (2015); Young Investigator Award from European Atherosclerosis Society (2015); Clinical Research Training Fellowship from Medical Research Council (2012-2015); Fellow of the Cambridge Commonwealth Society (2004); Rolleston Scholar of St John's College, University of Cambridge (2001)
(Additional) Languages spoken
- Cantonese - Native or bilingual
- Chinese - Native or bilingual
(I) BOOK CHAPTERS
Choudhury RP, Chai JT, Fisher EA
Biology and pathology of atherosclerosis (Book chapter) Oxford Textbook of Medicine: Cardiovascular Disorders Oxford University Press, 2016
Chai JT, Biasiolli L, Li L, Jezzard P, Handa A, Choudhury RP
Clinical vascular magnetic resonance imaging at high field (Book chapter) Vascular and Endovascular Consensus Update book, BIBA publishing, 2014
(II) REVIEW ARTICLES
Ruparelia N, Chai JT, Fisher EA, Choudhury RP
Inflammatory processes in cardiovascular disease: a route to targeted therapies Nature Rev Cardiol. 2016 Dec 1.
Alkhalil M, Chai JT, Choudhury RP
Plaque imaging to refine indications for emerging lipid-lowering drugs Eur Heart J Cardiovasc Pharmacotherapy. 2017 Jan;3(1):58-67
Chai JT, Choudhury RP
Cardiometabolic interventions – focus on transcriptional regulators
Eur J Cardiovasc Med 2013 Aug; 2(3):212-218
Chai JT, Digby JE, Choudhury RP
GPR109A and vascular inflammation
Curr Atheroscler Rep. 2013 May;15(5):325
(III) ORIGINAL RESEARCH
Chai JT, Ruparelia, N, Goel A, et al.
Differential gene expression in macrophages from human atherosclerotic plaques shows convergence on pathways impoicated by GWAS risk variants.
Arterioscler Thromb Vasc Biol, 2018 Nov; 38(11):2718-30
Alkhalil M, Biasiolli L, Akbar N, Gallassi F, Chai JT, et al.
T2 mapping MRI technique quantifies carotid plaque lipid, and its depletion after statin initiation, following acute myocardial infarction.
Atherosclerosis, 2018 Dec; 279:100-106
Alkhalil M, Biasiolli L, Chai JT, et al.
Quantification of carotid plaque lipid content with magnetic resonance T2 mapping in patients undergoing carotid endarterectomy.
PLoS One. 2017 Jul 26;12(7):e0181668.
Chai JT, Biasiolli L, Li L, Handa A, et al. Quantification of lipid-rich core in carotid atherosclerosis using T2 mapping with MRI – relation to clinical presentation
JACC Cardiovascular Imaging. 2016 Oct 6
Ruparelia N, Godec J, Lee R, Chai JT, et al.
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.
Eur Heart J. 2015 Aug 1;36(29):1923-34.
Chai JT, Digby JE, Ruparelia N, et al.
Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells PLoS ONE. 2013 May 2; 8(5): e62934.
- MA University of Cambridge 2006
- BA University of Cambridge 2002
- MB BChir University of Cambridge 2004
- DPhil in Cardiovascular Medicine University of Oxford 2016
- MRCP Royal College of Physicians 2008
- Post-CCT complex coronary intervention fellowship Royal Bournemouth Hospital 2017
Reference number 6112347
Details of entry to specialist register
- CCT, 2017
Affiliations / memberships
BCS and BCIS
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.
In the event of an urgent query following treatment, Bupa members should use the following contact details
Direct with myself via mobile: 07537 181168; or to attend Wexham Park Hospital Emergency Department.