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Professor Daniel Gale

Renal medicine

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About me

I conduct research into genetic kidney disease and run the genetic kidney disease clinical service for North London that provides care for patients and families with hereditary kidney problems, including Polycystic Kidney Disease, Alport Syndrome, unexplained familial kidney failure, complement disorders and other genetic conditions. Patients are frequently offered enrolment in clinical research studies, including those involving new treatments.

Using linkage mapping, next generation sequencing and other techniques I discovered (and identified the genetic defects responsible for) the diseases HIF2α erythrocytosis and pulmonary hypertension, which results from a defect in cellular oxygen sensing, and CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in people of Cypriot ancestry. I also study genetic factors important in other kidney diseases and, using genome wide association studies, have identified the genes important in a range of more common kidney diseases, including IgA nephropathy and Steroid Sensitive Nephrotic Syndrome.

Areas of interest

Genetic kidney disease; Complement-mediated kidney disease; MPGN; C3 glomerulopathy; Alport Syndrome; Polycystic kidney disease

Medical secretaries

  • Kim Levendale
  • 12th Floor Private Practice Unit Royal Free Hospital Pond Street London NW3 2QG
  • kim.levendale@nhs.net
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