Current NHS consultant posts held
Consultant Neurologist,
Milton Keynes and Oxford
Research interests
Epilepsy,
Autism,
Neuro-oncology
Personal interests
Tennis,
Piano,
Chess
Awards received
Wellcome Trust Research Training Fellowship,
MRC Clinician-Scientist Fellowship,
Simon's Foundation Investigator Award
Cancer Research UK Development Fund Award
(Additional) Languages spoken
Publications
Blassberg R, Jacob J. Lipid metabolism fattens up hedgehog signaling.
BMC Biol. 2017 Oct 26;15(1):95.
Turner MR, et al. Focal precentral gyrus involvement in osmotic demyelination.
Pract Neurol. 2017 Oct;17(5):410-411.
Blassberg R, et al. Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Hum Mol Genet. 2016 Feb 15;25(4):693-705
Jacob J. Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders.
Epilepsia. 2016 Feb;57(2):182-93.
Jacob J*, et al. Valproic Acid silencing of ascl1b/ascl1 results in the failure of serotonergic differentiation in a zebrafish model of Fetal Valproate Syndrome.
Dis Model Mech. 2013 Oct 17. PMID: 24135485
Jacob*, et al “A chemical-genetics approach to study the molecular pathology of central serotonin abnormalities in fetal valproate syndrome”
Lancet Feb 2013, S55.
Jacob J*, et al “Distinct neuronal identities specified by quantitative differences in the transcription factor, Ascl1”
Current Biology 2013 Mar 4; 23(5):412-8 2013 PMID: 23416099
Jacob J*, et al “Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the hindbrain”
Development 2009 136(14): 2477-85
Jacob J*, et al “Temporal control of neural diversity: common regulatory principles in insects and vertebrates?”
Development 2008; 135(21): 3481-9
Jacob J, et al. “Transcriptional cross-repression coordinates the temporal switch from motor to serotonergic neurogenesis in the hindbrain”
Nat Neurosci, 2007; Nov; 10(11):1433-9 (Paper flagged by Faculty of 1000)
Hilton DA, et al. Complications following sural and peroneal nerve biopsies”
JNNP 2007; Jun 5
Jacob J and Briscoe J “Gli proteins and the control of spinal cord patterning”
EMBO Reports 2003; 4(8): 761-5
Jacob J, et al “The clinico-pathological spectrum of Rosenthal Fibre Encephalopathy.....”
JNNP, 2003; 74(6): 807-10
Joseph FG, Jacob J and Carrington D “SSPE – a forgotten disease?”
European Journal of Neurology 2002; 9(5): 541-5
Jacob J, et al “Molecules and mechanisms in motor neuron specification and axon pathfinding”
Bioessays 2001; 23:582-595
Jacob J, et al “Role of the target in the pathfinding of facial visceral motor axons”
MCN 2000; 16(1): 14-26
Jacob J, Guthrie S “Facial visceral motor neurons display specific rhombomere origin and axon pathfinding behaviour in the chick”
J Neurosci 2000; 20(20): 7664-71
Courses offered to GPs
Epilepsy,
Headache,
General Neurology
