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Last updated: 29 Jun 2020
- Movement disorders
I trained in clinical neurology in London, at the National Hospital for Neurology and Neurosurgery, Queen Square, and in the Southwest. I was appointed Honorary Consultant Neurologist at the world-renowned National Hospital in 2005, and remained in post until 2013. Over that period I also held a prestigious Medical Research Council Clinician-Scientist Fellowship. In 2014 I ceased practising clinical neurology at the National Hospital choosing to work closer to home. I have a broad range of expertise in clinical neurology, in particular epilepsy and movement disorders. As a clinical academic I also hold the title of Honorary Senior Clinical Research Fellow at the University of Oxford. Thanks to funding from Cancer Research UK Oxford, I am actively involved in laboratory research in brain cancer, focusing on the development of novel human pluirpotent stem cell models of brain cancer with collaborators in the University of Oxford.
Areas of interest
Headache; Epilepsy; Movement Disorders; General Neurology; Neuro-Oncology
Current NHS consultant posts held
Milton Keynes and Oxford
Wellcome Trust Research Training Fellowship,
MRC Clinician-Scientist Fellowship,
Simon's Foundation Investigator Award
Cancer Research UK Development Fund Award
Cancer Research UK Clinical Research Training Fellowship Award
Chakraborty A, Jacob J. Resolution of ptosis with application of ice pack. British Medical Journal 2019/20 (provisional offer subject to editorial revision)
Blassberg R, Jacob J. Lipid metabolism fattens up hedgehog signaling.
BMC Biol. 2017 Oct 26;15(1):95.
Turner MR, et al. Focal precentral gyrus involvement in osmotic demyelination.
Pract Neurol. 2017 Oct;17(5):410-411.
Blassberg R, et al. Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Hum Mol Genet. 2016 Feb 15;25(4):693-705
Jacob J. Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders.
Epilepsia. 2016 Feb;57(2):182-93.
Jacob J*, et al. Valproic Acid silencing of ascl1b/ascl1 results in the failure of serotonergic differentiation in a zebrafish model of Fetal Valproate Syndrome.
Dis Model Mech. 2013 Oct 17. PMID: 24135485
Jacob*, et al “A chemical-genetics approach to study the molecular pathology of central serotonin abnormalities in fetal valproate syndrome”
Lancet Feb 2013, S55.
Jacob J*, et al “Distinct neuronal identities specified by quantitative differences in the transcription factor, Ascl1”
Current Biology 2013 Mar 4; 23(5):412-8 2013 PMID: 23416099
Jacob J*, et al “Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the hindbrain”
Development 2009 136(14): 2477-85
Jacob J*, et al “Temporal control of neural diversity: common regulatory principles in insects and vertebrates?”
Development 2008; 135(21): 3481-9
Jacob J, et al. “Transcriptional cross-repression coordinates the temporal switch from motor to serotonergic neurogenesis in the hindbrain”
Nat Neurosci, 2007; Nov; 10(11):1433-9 (Paper flagged by Faculty of 1000)
Hilton DA, et al. Complications following sural and peroneal nerve biopsies”
JNNP 2007; Jun 5
Jacob J and Briscoe J “Gli proteins and the control of spinal cord patterning”
EMBO Reports 2003; 4(8): 761-5
Jacob J, et al “The clinico-pathological spectrum of Rosenthal Fibre Encephalopathy.....”
JNNP, 2003; 74(6): 807-10
Joseph FG, Jacob J and Carrington D “SSPE – a forgotten disease?”
European Journal of Neurology 2002; 9(5): 541-5
Jacob J, et al “Molecules and mechanisms in motor neuron specification and axon pathfinding”
Bioessays 2001; 23:582-595
Jacob J, Guthrie S “Facial visceral motor neurons display specific rhombomere origin and axon pathfinding behaviour in the chick”
J Neurosci 2000; 20(20): 7664-71
Courses offered to GPs
- Fellow of the Royal College of Physicians (FRCP) Royal College of Physicians (London) 2012
- PhD Kings College London, Guy's Campus 2000
- MRC Clinician-Scientist MRC National Institute for Medical Research 2003
Reference number 3586512
Professional bodies (positions held - last 3 yrs)
- Ordinary Member Association of British Neurologists 2005
- Fellow Royal College of Physicians 2012
- Member International League Against Epilepsy (ILAE) 2014
Details of entry to specialist register
- Certificate of Completion of Specialist Training, 2005
Affiliations / memberships
Association of British Neurologists
British Medical Association
Royal College of Physicians
International League Against Epilepsy
- BMI The Saxon Clinic, MK6 5LR
- 14:30 - 18:00
- 01908 665533
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.
In the event of an urgent query following treatment, Bupa members should use the following contact details