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Professor Sharp qualified from Edinburgh Medical School in 1998 and was appointed as a Consultant Cardiologist at the Royal Devon and Exeter Hospital in 2011. He was appointed Honorary Associate Professor at the University of Exeter in 2018.
He conducted his early training at the Royal Infirmary of Edinburgh, before moving to London for his senior clinical training. He completed the prestigious Milan-Imperial Interventional Cardiology Fellowship programme, having spent a year in San Raffaele and Columbus Hospitals, Milan, Italy, under the tutelage of Professor Antonio Colombo. He also spent three years training in interventional cardiology at St Mary’s Hospital and The Hammersmith Hospital (Imperial College Hospitals) in London.
Professor Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and now leads a large research programme at the Royal Devon and Exeter Hospital. He has been Principal Investigator in more than 30 ethically-approved research trials since 2012 and has published extensively. He is regularly invited to lecture at national and international conferences in the fields of coronary artery disease, pulmonary embolism and hypertension.
His specialist interests include:
Hypertension – Professor Sharp is lead investigator for a research study looking at novel mechanisms of blood pressure control in newly diagnosed high blood pressure. He is on the steering committee of a major international randomised trial of renal denervation, a one-off treatment for high blood pressure. He has recruited patients to six trials of renal denervation, two of which he recently co-authored and published in The Lancet medical journal, showing that a single one-hour, local anaesthetic procedure can persistently lower blood pressure.
Intra-coronary physiology to assess the causes of chest pain – Professor Sharp is on the steering committee of a major international trial looking at why some patients fail to gain symptomatic relief from coronary stenting and was one of the first investigators in the UK to use co-registration technology to optimise stent selection and placement. He recently co-authored a publication in this area in the New England Journal of Medicine, the world’s pre-eminent medical journal.
Complex angioplasty and stenting of coronary artery disease – Professor Sharp set up the rotablation service at the Royal Devon and Exeter Hospital in 2012 and is one of the highest volume operators in the Peninsula. Results of his coronary stenting cases can be found on the British Cardiac Interventional Society national website by entering ‘Sharp’ into the operator name section.
Pulmonary embolism – Professor Sharp is the Chief Investigator for a national multicentre study of the interventional management of pulmonary embolism and lectures internationally on new treatments for blood clots in the lung.
Intracoronary imaging – Professor Sharp is Course Director of Advances in Intravascular Imaging, a course that recruits faculty from across the world to teach interventional cardiologists the subtleties of intravascular ultrasound.
He sees patients with a broad range of cardiac symptoms, including palpitations, chest pain, breathlessness and high blood pressure.
Areas of interest
Dr Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and now leads a growing research programme at the Royal Devon and Exeter Hospital in the fields of coronary artery disease and hypertension. He has published extensively and lectures internationally in the fields of coronary artery disease and hypertension.
1. Azizi M et al RADIANCE-HTN Investigators. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial.
2. Al-Lamee R et al. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA.
3. Kikuta Y et al Pre-Angioplasty Instantaneous Wave-Free Ratio Pullback Predicts Hemodynamic Outcome In Humans With Coronary Artery Disease: Primary Results of the International Multicenter iFR GRADIENT Registry.
JACC Cardiovasc Interv. 2018
4. Al-Lamee R et al; ORBITA investigators. Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.
5. Schmieder RE et al. Phase II randomized sham-controlled study of renal denervation for individuals with uncontrolled hypertension - WAVE IV.
J Hypertens. 2017
6. Townsend RR et al; SPYRAL HTN-OFF MED trial investigators*. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial.
7. Davies JE et al. Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI.
N Engl J Med. 2017
8. Sharp AS et al. Renal artery sympathetic denervation: observations from the UK experience.
Clin Res Cardiol. 2016
9. Petraco R et al Real-time use of instantaneous wave-free ratio: Results of the ADVISE in-practice: An international, multicenter evaluation of instantaneous wave-free ratio in clinical practice.
Am Heart J.
10. Barron AJ et al. Long-term antihypertensive treatment fails to improve E/e' despite regression of left ventricular mass: an Anglo-Scandinavian cardiac outcomes trial substudy.
11. Tapp RJ, Sharp A et al; ASCOT Investigators. Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.
12. Sharp AS et al on behalf of the ASCOT Investigators. Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy.
European Heart Journal.
Courses offered to GPs
Exeter Heart run educational days in cardiology for GPs and primary care nurses.
Outcomes (checked and approved by medical professional body)
Please click on this link if you would like to see information about this healthcare professional’s performance compared to their peers, as published by their medical professional body.http://www.bcis.org.uk/pages/page_box_contents.asp?pageid=805&navcatid=88
Dr Sharp's standardised, nationally reported procedural outcomes data show a major adverse cardiac and cerebrovascular complication rate of 1% (below the expected rate of 3.4%).
Details of the breakdown of procedures performed can be found here: http://www.bcis.org.uk/pages/page_box_contents.asp?pageid=805&navcatid=88
- Fellow Royal College of Physicians 2015
- MD University of Edinburgh 2012
- MBChB University of Edinburgh 1998
Reference number 4530660
Affiliations / memberships
British Cardiac Society
British Cardiovascular Interventional Society
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