Dr Alastair O'Brien: Gastroenterology , General (internal) medicine

Dr Alastair O'Brien

Gastroenterology, General (internal) medicine


  • Fee assured

Specialises in

  • Endoscopy
  • Hepatobiliary

About me

Dr Alastair O'Brien studied medicine at Guy's and St Thomas' Hospitals and qualified in 1994. He underwent specialist training in liver disease, gastroenterology and general medicine in London. He was appointed as a Clinical Senior Lecturer at University College London in 2007.
He was appointed Reader in 2014.

Dr O'Brien is a highly experienced with non-invasive assessment of liver fibrosis (Fibroscan®).

Dr O'Brien was a Medical Research Council clinical training fellow and completed his PhD thesis under Professor Mervyn Singer at UCL. This work led to a landmark paper on the use of terlipressin as rescue therapy for norepinephrine-resistant septic shock that was published in the Lancet.

Continuing his research work at the university allows Dr O'Brien to bring his patient the latest treatments available to ensure a positive outcome.

He is associate editor for BMJ open Gastroenterology and co-writes the hepatology chapter for the best selling textbook Kumar and Clark's Clinical Medicine, 9th Edition.

Infection is the most serious problem facing patients with advanced liver cirrhosis and Dr O'Brien's pioneering work at UCL has led the exciting discovery that Prostglandin E2 mediates white cell dysfunction in these patients. We hope that our Wellcome Trust and Department of Health funded clinical trial across 40 sites will lead to improved survival rates in these patients.

Dr O'Brien currently hold grants as Principal or Co-Investigator from the Wellcome Trust, BBSRC, Department of Health and Medical Research Council.

Areas of interest

Fibroscan; Non Alcoholic Fatty Liver Disease; Viral Hepatitis; Alcohol Related Chronic Liver Disease; Irritable Bowel Syndrome; autoimmune hepatitis; primary biliary cirrhosis; cirrhosis; dyspepsia; abdominal pain; primary sclerosing cholangitis; deranged liver function tests; gallstones

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Information for healthcare professionals

Information for healthcare professionals (Bupa patients only, last 12 months)

Procedures completed

  • X3510

    IV sedation administered by operator - (1-5)

    London Clinic (1-5)

  • G6500

    Diagnostic oesophago-gastro-duodenoscopy (OGD) includes forceps biopsy, biopsy urease test and dye spray - (1-5)

    London Clinic (1-5)

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