Dr Alastair O'Brien

Gastroenterology, General (internal) medicine


  • Fee assured

This healthcare professional let us know that they are currently:

  • Accepting new patients
  • Available for:
    • Phone consultations
    • Video consultations

Last updated: 24 Apr 2020

Specialises in

  • Endoscopy
  • Hepatobiliary

About me

Dr Alastair O'Brien studied medicine at Guy's and St Thomas' Hospitals and qualified in 1994. He underwent specialist training in liver disease, gastroenterology and general medicine in London. He was appointed as a Clinical Senior Lecturer at University College London in 2007 and Reader in 2014.

I am highly experienced with non-invasive assessment of liver fibrosis (Fibroscan®).

I was a Medical Research Council clinical training fellow and completed my PhD under Professor Mervyn Singer at UCL. This work led to a landmark paper on the use of terlipressin as rescue therapy for septic shock that was published in the Lancet.

Continuing my research allows me to bring his patient the latest treatments available to ensure a positive outcome.

I am associate editor for BMJ open Gastroenterology and co-write the hepatology chapter for the best selling textbook Kumar and Clark's Clinical Medicine, 9th Edition.

My pioneering work at UCL has led the exciting discovery that Prostglandin E2 mediates white cell dysfunction in patients with advanced liver disease. My laboratory research group currently receive research funding form the Wellcome Trust, Department of Health, Medical Research Council & BBSRC. I also run the largest clinical trial in advanced liver disease currently recruiting worldwide.

Areas of interest

Fibroscan; Non Alcoholic Fatty Liver Disease; Viral Hepatitis; Alcohol Related Chronic Liver Disease; Irritable Bowel Syndrome; autoimmune hepatitis; primary biliary cirrhosis; cirrhosis; dyspepsia; abdominal pain; primary sclerosing cholangitis; deranged liver function tests; gallstones; nausea; vomiting; hepatitis b; Hepatitis C; liver infections; liver failure; liver dysfunction; assessment of liver function

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