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- Paediatric respiratory medicine
All aspects of paediatric respiratory medicine including
Areas of interest
I am a Consultant Respiratory Paediatrician, one of only a few in the UK who does nothing else. My NHS practice is at the King's College.
My specialist areas are Asthma, Allergy, Chronic Cough, Recurrent Chest infections, Sleep medicine, Wheezy infants, Cystic Fibrosis, Lung disease, snoring,
Following on from my doctoral thesis, my research interests centre on asthma and Vitamin D.
I have been invited to give lectures in many countries of Europe, the UAE, USA and India.
Current NHS consultant posts held
Consultant in Paediatric Respiratory Medicine King’s College Hospital, London
Senior Lecturer in Paediatric Respiratory Medicine, King’s College London, School of Medicine
Sickle lung disease
2012: Lorber Prize by Royal College of Paediatrics and Child Health (RCPCH)
2010: Asthma UK travel fellowship
2009: The James fellowship, British Medical Association (£40850) awarded to pursue my vitamin D and severe asthma in children project
2009: BPRS fellowship for RCPCH, Spring Meeting
2008: BPRS travel fellowship
2000: S.S. Manchanda Neonatology Research Gold Medal-1999-2000
2000: Ved & Sita Ram Memorial Gold Medal for the best doctor in Neonatology for the year 1999-2000
1. Aberrant IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax 2014
Children with moderate and severe therapy resistant asthma are characterised immunologically by defective anti-inflammatory interleukin (IL)-10 expression; in vitro, steroids drive IL-10 expression, but also IL-17A, particularly in asthmatics. However, active vitamin D potentiates steroid-induced IL-10 but not IL-17A
2. Vitamin D binding protein and asthma severity in children. J Allergy Clin Immunol 2012
In this cross-sectional study, we reported that bronchoalveolar lavage (BAL), but not serum, levels of VDBP are significantly higher in STRA and that BAL VDBP levels inversely correlate with asthma severity, as assessed by the asthma control test, spirometry, and inhaled corticosteroids usage. These data highlight the potential importance of the vitamin D axis, beyond vitamin D itself, in children with asthma.
3. Vitamin D and Asthma in children. Paediatr Respir Rev 2012;
This review summarises the current understanding and uncertainties regarding the effect of vitamin D deficiency and insufficiency in children with asthma.
4. 1α,25-Dihydroxyvitamin D3 Promotes CD200 Expression by Human Peripheral and Airway-Resident T Cells. Thorax 2012
The induction of CD200, an immunoregulatory molecule, on human peripheral and airway T cells is a novel mechanism whereby 1α25- dihydroxyvitamin D3 may act to reduce down airway inflammation and maintain respiratory health
5. 1,25- dihydroxyvitamin D3 promotes distinct Foxp3 and IL-10 expression by CD4+ T cells. Eur J Immunol 2012
We reported that 1,25-dihydroxyvitamin D3 increases the numbers of both IL-10+ and Foxp3+ T regulatory cells. In a translational setting, these data suggest that 1,25- dihydroxyvitamin D3, over a broad concentration range will modulate airway inflammation via T-regulatory cells.
6. Relationship Between Serum Vitamin D, Disease Severity and Airway Remodelling in Children with Asthma. Am J Respir Crit Care Med 2011
We reported that the children with severe therapy resistant asthma (STRA) have lower serum vitamin D levels. Reduced vitamin D levels in STRA are associated with lower lung function, poor asthma control, increased medication use, and asthma exacerbations. The serum vitamin D level is inversely associated with airway smooth muscle mass, the first time an association between Vitamin D and airway structure has been demonstrated.
- MBBS , 1996
- MD , 2000
- MRCPCH , 2004
- DNB , 2000
- MD (Res) Imperial College, London 2014
Details of entry to specialist register
- CCT, 2010
Affiliations / memberships
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.