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External resources

• The Yorkshire Clinic

Current NHS consultant posts held

Consultant Orthopaedic and Trauma Surgeon
Bradford Teaching Hospitals NHS Trust

Research interests

I obtained a research fellowship from Arthritis Research UK and the Royal College for Surgeons of England to investigate the causes of osteoarthritis in a leading UK laboratory. This work has helped our understanding of osteoarthritis, the leading cause for hip and knee replacements. I continue my interest in the causes and treatment of osteoarthritis at both the molecular biological and surgical level.
I have also published research on the management of fractures around hip replacements.

Personal interests

In my spare time I enjoy trying to keep fit by running and cycling. I have an interest in classic cars and enjoy going on rallies and similar motoring events in my classic car. I also enjoy going clay pigeon shooting with my boys.

Awards received

Arthritis Research Campaign (ARC) Clinical Research Training Fellowship. June 2001.

Action Research Training Fellowship May 2001.

Royal College of Surgeons of England Research Training Fellowship. June 2001.

Arthritis Research Campaign Travel Award. February 2002.

Publications

A Conservative Approach for Proximal Interphalangeal Arthroplasty. NRM.Fahmy, A.Lavender, CJ Brew. Journal of Hand Surgery [Br] 2001 Jun;26(3):235-7.

Increased collagen 1 expression in osteoarthritic cartilage suggests some loss of normal chondrocyte phenotype. CJ Brew, JG Andrew, R Boot-Handford, TE Hardingham. Transactions of the Orthopaedic Research Society 2004, 29.940.

Late osteoarthritic cartilage shows down regulation of SOX9 and aggrecan expression but little evidence of chondrocyte hypertrophy. CJ Brew, JG Andrew, R Boot-Handford, TE Hardingham. Transactions of the Orthopaedic Research Society 2004, 29.938.

SOX9 Transduction of a Human Chondrocytic Cell Line Identifies Novel Genes Regulated in Primary Human Chondrocytes and in Osteoarthritis
Simon R Tew, Peter D Clegg, Christopher J Brew, Colette M Redmond and Timothy E Hardingham. Arthritis Res. Ther. 2007;9(5):R107

Gene expression in human chondrocytes in late OA is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy
Brew, CJ., Clegg PD., Boot-Handford, RP., Andrew JG, and Hardingham, T E.
Ann. Rheum. Dis. 2010. 69(1): 234-240.

Iliopsoas Tendonitis After Total Hip Arthroplasty Caused by Overhang of a Collared Femoral Prosthesis. Christopher J. Brew, Ian Stockley, Andrew J. Grainger, Martin H. Stone.
J Arthroplasty. 2011 Apr;26(3):504.e17-9. Epub 2010 Jan 21

Tuberculosis infection of the talonavicular joint. C. J. Brew, V. Rao, J. Shanker. The Foot. 2010. 20(4) 146-148.

Scaling digital radiographs for templating in total hip arthroplasty using conventional acetate templates independent of calibration markers.
Brew, CJ, Simpson, P, Whitehouse, SL, Donnelly,W, Crawford, RW, Hubble, MJ.
J Arthroplasty, 2012. 27(4) 643-7.

Brew CJ, Wilson LJ, Whitehouse SL, Hubble MJW, Crawford RW. Cement-in-cement revision for selected Vancouver type B1 femoral periprosthetic fractures: A biomechanical analysis. J Arthroplasty 2012;epub ahead of print 2013;28(3):521-5

Simpson PMS, Brew CJ, Whitehouse SL, Crawford RW, Donnelly WJ. Complications of peri-operative warfarin therapy in total knee arthroplasty. J Arthroplasty – accepted 22 October 2012

Crawford RW, Whitehouse SL, Brew CJ, Wilson LJ, Hubble MJW. Author reply: Cement-in-cement revision for selected Vancouver type B1 femoral periprosthetic fractures: a biomechanical analysis. J Arthroplasty 2013; epub ahead of print doi: 10.1016/j.arth.2013.05.021

Courses offered to GPs

Faculty on Leeds Hip and Knee Instructional Course.