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Heart failure. Cardiac issues in cancer patients including heart failure induced by chemotherapy and cardiotoxicity due to novel cancer treatments such as Herceptin® (trastuzumab). Cardiac gene therapy. Takotsubo cardiomyopathy, also known as acute stress cardiomyopathy or ‘broken heart syndrome’.
Areas of interest
Heart Failure; Cardiomyopathy; Takotsubo Syndrome; Chemotherapy cardiotoxicity and heart problems in cancer patients e.g. doxorubicin, epirubicin, Herceptin, Perjeta, Lapatinib, Avastin, Imatinib, Sunitinib, Sorafenib, Pazopanib, Regorafenib, Trametinib; Hypertension; Gene therapy
Current NHS consultant posts held
Senior Lecturer and Honorary Consultant Cardiologist
Royal Brompton Hospital
Gene therapy and biological therapies for cardiac repair
Chemotherapy cardiotoxicity and cardiac problems in cancer patients
Stress and the heart
Winner of the Inaugural Bernard and Joan Marshall Young Investigator award: British Society for Cardiovascular Research (BSCR) 2010
Imperial College Research Excellence Award 2010
British Cardiac Society Young Investigator award - Basic Science: Winner 2009
Medical Research Society The Raftery Prize in Cardiovascular Sciences 2008
Royal Society of Medicine 2007 Cardiology Section President’s Medal Winner
Medical Research Council Clinical Research Training Fellowship 2005
Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J. J Mol Cell Cardiol. 2014 67:38-48.
Takotsubo cardiomyopathy: an integrated multi-imaging approach. Bossone E, Lyon A, Citro R, Athanasiadis A, Meimoun P, Parodi G, Cimarelli S, Omerovic E, Ferrara F, Limongelli G, Cittadini A, Salerno-Uriarte JA, Perrone Filardi P, Schneider B, Sechtem U, Erbel R. Eur Heart J Cardiovasc Imaging. 2014 15:366-77.
Targeting the autonomic nervous system: Measuring autonomic function and novel devices for heart failure management. Patel HC, Rosen SD, Lindsay A, Hayward C, Lyon AR, di Mario C. Int J Cardiol. 2013 170:107-17.
SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope. Sikkel MB, Hayward C, Macleod KT, Harding SE, Lyon AR. Br J Pharmacol. 2014 171:38-54.
Cardiac contractility modulation therapy in advanced systolic heart failure. Lyon AR, Samara MA, Feldman DS. Nature Reviews Cardiology. 2013 10:584-98.
Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy. Redfors B, Shao Y, Wikström J, Lyon AR, Oldfors A, Gan LM, Omerovic E. Eur Heart J Cardiovasc Imaging. 2014 15:152-7.
Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease. Toepfer C, Caorsi V, Kampourakis T, Sikkel MB, West TG, Leung MC, Al-Saud SA, Macleod KT, Lyon AR, Marston SB, Sellers JR, Ferenczi MA. J Biol Chem. 2013 288(19):13446-54.
Mind the store: Modulating Ca2+ reuptake with a leaky sarcoplasmic reticulum. Louch WE and Lyon AR. Cardiovascular Research 2013309(9):896-908. Invited Editorial.
Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. Gulati A, Jabbour A, Ismail TF, Guha K, Khwaja J, Raza S, Morarji K, Brown TD, Ismail NA, Dweck MR, Di Pietro E, Roughton M, Wage R, Daryani Y, O'Hanlon R, Sheppard MN, Alpendurada F, Lyon AR, Cook SA, Cowie MR, Assomull RG, Pennell DJ, Prasad SK. JAMA. 2013 309:896-908
Courses offered to GPs
How to manage diastolic dysfunction in primary care
Heart problems in cancer patients
Stress and the heart
- Medicine Oxford University 1995
Reference number 4530330
Affiliations / memberships
Lead for Heart Failure Research Theme, Cardiovascular Biomedical Research Unit, Royal Brompton Hospital (2011-present)
Clinical Lead for Cardio-Oncology Service, Royal Brompton Hospital (2011-present)
Chair of UK Cardio-Oncology Consortium (2012- present)
Member of Heart Failure Association Translational Research Committee (European Society of Cardiology: 2012-present)
Co-chair of Heart Failure Association Takotsubo Cardiomyopathy Committee (European Society of Cardiology: 2012-present)