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Graduated MB ChB in 1971 from Leeds Medical School having intercalated Hons BSc in Biochemistry in Relation to Medicine in 1968. Trained in general medicine and gastroenterology at Hope Hospital, Salford (now Salford Royal NHS Trust), Manchester Royal Infirmary and Royal Victoria Infirmary, Newcastle upon Tyne. Gained MRCP (UK) in 1974 and elected FRCP (London) in 1993. Awarded MD (1980) and PhD (1987) for research into small intestinal and colonic transport physiology in health and disease. Gained further training in research in the Section of Digestive Diseases, Department of Internal Medicine, Yale University, USA (1981-1983), leading to award of prestigious Medical Research Council Senior Clinical Fellowship (1983-1989) to enable establishment of independent research programme in UK. Long track record of research funded from a variety of sources, including Medical Research Council, Wellcome Trust, Royal Society, and British Heart Foundation. Currently collaborate with colleagues in Leeds, Germany and USA. Moved to Leeds in 1998 as an NHS consultant gastroenterologist and became Professor of Clinical Science in 2000. Retired from the University of Leeds in 2016, becoming Emeritus Professor of Clinical Science, but continued to work as NHS consultant gastroenterologist within Leeds Teaching Hospital Trust until September 2019. Currently undertake private practice at Spire Leeds and Spire Methley Park Hospitals, and also see NHS patients at Living Care, Thorpe Park, Leeds.
Areas of interest
Dyspepsia (indigestion); swallowing disorders; investigation and management of ulcerative colitis and Crohn's disease and other diseases / disorders causing diarrhoea, constipation and abdominal pain; functional bowel disorders; gastro-intestinal endoscopy (gastroscopy and flexible sigmoidoscopy +/- polypectomy).
Current NHS consultant posts held
Emeritus Professor of Clinical Science/Consultant Physician & Gastroenterologist. Retired from NHS consultant post at St James's University Hospital, Leeds 31 August 2019. Since 1 September 2019 have worked in private practice, plus NHS clinics for LivingCare, Leeds..
Intestinal fluid and electrolyte transport in health and disease, using state-of-the-art techniques to investigate pathophysiological mechanisms underlying a variety of intestinal disorders (see PubMed via Google).
Medical education and training. Currently Member of Court of Examiners, Royal College of Surgeons of England, and Member of Board of Examiners, Royal College of Physicians of London.
Fellowship of American Gastroenterological Association awarded 2008 for outstanding contributions to research.
Fellow of Association of Physicians of GB and Ireland (elected 2021).
Jennings J, Scott N and Sandle GI. A 25-year old woman with recurrent anemia. J Clin Med Img 2021; V5(17): 1-2.
Bowley KA and Sandle GI. Calmodulin antagonist W‐7 enhances intermediate conductance Ca2+‐ sensitive basolateral potassium channel (IKCa) activity in human colonic crypts. J Memb Biol 2021; 254:423–428.
de Sá, F, et al. Vitamin D reverses disruption of gut epithelial barrier function caused by Campylobacter jejuni. Int J.Mol Sci 2021,22,8872.
Rehman S, et al. Parallel intermediate conductance K and Cl channel activity mediates electroneutral K exit across basolateral membranes in rat distal colon. Am J Physiol Gastrointest Liver Physiol 2020; 319: G142–G150.
Rajendran VM and Sandle GI. Colonic potassium absorption and secretion in health and disease. Comp Physiol 2018; 8: 1513-1536.
Al-Hazza A, et al. Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis. Biochem Biophys Res Comm 2016; 470: 473-478.
Perry MD, et al. Segmental differences in unregulated apical potassium channels in mammalian colon during potassium adaptation. Am J Physiol Gastrointest Liver Physiol 2016; 311: G785-G793.
Robins GG and Sandle GI. Liddle-mutation of the beta-subunit, but not the gamma-subunit, attenuates protein kinase C-mediated inhibition of human epithelial sodium channels (ENaC). J Memb Biol 2016; 249: 271-279.
Robins GG and Sandle GI. Calcium rapidly down-regulates human renal epithelial sodium channels via a W-7-sensitive mechanism. J Memb Biol 2014; 247: 729-737.
Linley J, et al. Evidence that two distinct cell types secrete chloride and potassium in human colon. Gut 2014; 63; 472-479.
Kanthesh BM et al. Enhanced K secretion in dextran sulcate-induced colitis reflects up regulation of large conductance apical K channels (BK; Kcnma1). Am J Physiol Cell Physiol 2013; 305; C972-C980.
Robins GG et al. Rapid stimulation of human renal ENaC by cAMP in Xenopus leaves oocytes. J Physiol Biochem 2013; 69; 419-427.
Sandle GI. Human colonic potassium channel expression and function in ulcerative colitis. Genes Nutr 2012; 6 (suppl 1); S13-S17.
Al-Hazza A, et al. Potential role of reduced basolateral potassium (IKCa3.1) channel expression in the pathogenesis of diarrhoea in ulcerative colitis. J Pathol 2012; 226: 463–470.
Sandle GI, Rajendran VM, Cyclic AMP-induced K secretion occurs independently of Cl secretion in rat distal colon. Am J Physiol Cell Physiol 2012; 303: C328-C333.
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Zero rates for re-admission, infection and mortality after upper and lower gastrointestinal endoscopies. Have not performed colonoscopies since November 2017 (currently perform flexible sigmoidoscopes and gastroscopies), but previously had >90% caecal completion rate and colonic polyp detection rate consistent with national standards. High rate of re-referrals when patients have recurrence of 'old' symptoms or develop new ones.
- BSc (Hons 2i) University of Leeds 1968
- MB ChB University of Leeds 1971
- MD University of Leeds 1980
- MRCP(UK) Royal College of Physicians of London 1974
- PhD University of Manchester 1987
- FRCP Royal College of Physicians of London 1993
- Fellow of American Gastroenterological Association American Gastroenterological Association 2008
- Senior Research Fellow Yale University School of Medicine 1980
Reference number 1509287
Professional bodies (positions held - last 3 yrs)
- MRCP examiner Royal College of Physicians of London 2019
Details of entry to specialist register
- G I Sandle, 1981
Affiliations / memberships
Fellow, American Gastroenterological Association.
Fellow, Association of Physician of Great Britain & Ireland.
- Spire Leeds Hospital, LS8 1NT
- 09:00 - 12:00
- 0113 218 5908
- Spire Leeds Hospital, LS8 1NT
- 09:00 - 12:30
- 0113 218 5908
- Spire Methley Park Hospital, LS26 9HG
- 10:00 - 13:00
- 01977 664217
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.
In the event of an urgent query following treatment, Bupa members should use the following contact details
Spire Leeds Hospital 0113-2693939
Spire Methley Park Hospital 01977 518518
or Prof Sandle 07484 301952