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Last updated: 30 Apr 2020
Graduated MB ChB in 1971 from Leeds Medical School having intercalated Hons BSc in Biochemistry in Relation to Medicine in 1968. Trained in general medicine and gastroenterology at Hope Hospital, Salford, Manchester Royal Infirmary and Royal Victoria Infirmary, Newcastle upon Tyne. Gained MRCP (UK) in 1974 and elected FRCP (London) in 1993. Awarded MD (1980) and PhD (1987) for research into small intestinal and colonic transport physiology in health and disease. Gained further training in research in the Section of Digestive Diseases, Department of Internal Medicine, Yale University, USA (1981-1983), leading to award of prestigious Medical Research Council Senior Clinical Fellowship (1983-1989) to enable establishment of independent research programme in UK. Long track record of research funded from a variety of sources, including Medical Research Council, Wellcome Trust, Royal Society, and British Heart Foundation. Currently collaborate with colleagues in Leeds, Germany and USA.
Areas of interest
Dyspepsia (indigestion); Investigation and management of ulcerative colitis and Crohn's disease and other diseases / disorders causing diarrhoea, constipation and abdominal pain; Functional bowel disorders; Gastro-intestinal oncology; Gastro-intestinal endoscopy (gastroscopy and flexible sigmoidoscopy +/- colonic polypectomy).
Current NHS consultant posts held
Emeritus Professor of Clinical Science/Consultant Physician & Gastroenterologist. Retired from NHS consultant post at St James's University Hospital, Leeds 31 August 2019. Entirely private clinical practice since 1 September 2019.
Intestinal fluid and electrolyte transport in health and disease, using state-of-the-art techniques to investigate pathophysiological mechanisms underlying a variety of intestinal disorders (see PubMed via Google).
Medical education and training. Currently Member of Court of Examiners, Royal College of Surgeons of England, and Member of Board of Examiners, Royal College of Physicians of London.
Fellowship of American Gastroenterological Association awarded 2008 for outstanding contributions to research.
1. Rajendran VM and Sandle GI. Colonic potassium absorption and secretion in health and disease. Comp Physiol 8: 1513-1536, 2018.
2. Al-Hazza A, et al. Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis. Biochem Biophys Res Comm 470: 473-478, 2016.
3. Perry MD, et al. Segmental differences in unregulated apical potassium channels in mammalian colon during potassium adaptation. Am J Physiol Gastrointest Liver Physiol 311: G785-G793, 2016.
4. Robins GG and Sandle GI. Liddle-mutation of the beta-subunit, but not the gamma-subunit, attenuates protein kinase C-mediated inhibition of human epithelial sodium channels (ENaC). J Memb Biol 249: 271-279, 2016.
5. Robins GG and Sandle GI. Calcium rapidly down-regulates human renal epithelial sodium channels via a W-7-sensitive mechanism. J Memb Biol 247: 729-737, 2014.
6. Linley J, et al. Evidence that two distinct cell types secrete chloride and potassium in human colon. Gut 63; 472-479, 2014.
7. Kanthesh BM et al. Enhanced K secretion in dextran sulcate-induced colitis reflects up regulation of large conductance apical K channels (BK; Kcnma1). Am J Physiol Cell Physiol 305; C972-C980, 2013.
8. Robins GG et al. Rapid stimulation of human renal ENaC by cAMP in Xenopus leaves oocytes. J Physiol Biochem 69; 419-427, 2013.
9. Sandle GI. Human colonic potassium channel expression and function in ulcerative colitis. Genes Nutr 6 (suppl 1); S13-S17, 2012.
10. Al-Hazza A, et al. Potential role of reduced basolateral potassium (IKCa3.1) channel expression in the pathogenesis of diarrhoea in ulcerative colitis. J Pathol 226: 463–470, 2012.
11. Sandle GI, Rajendran VM, Cyclic AMP-induced K secretion occurs independently of Cl secretion in rat distal colon. Am J Physiol Cell Physiol 303: C328-C333, 2012.
12. Sandle GI. Infective and inflammatory diarrhoea: mechanisms and opportunities for novel therapies. Curr Opin Pharmacol 11:634–639, 2011.
13. Loganathan A, et al. Basolateral potassium (IK) channel inhibition prevents increased colonic permeability induced by chemical hypoxia, Am J Physiol Gastrointest Liver Physiol 300: G146-G153, 2011.
14. Perry MD, Sandle GI. Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. Am J Physiol Gastrointest Liver Physiol 297: G159-G167, 2009.
15. Sandle, GI, et al. Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis. J Pathol 212: 66–73, 2007.
Zero rates for re-admission, infection and mortality after upper and lower gastrointestinal endoscopies. Have not performed colonoscopies since November 2017 (currently perform flexible sigmoidoscopes and gastroscopies), but previously had >90% caecal completion rate and colonic polyp detection rate consistent with national standards. High rate of re-referrals when patients have recurrence of 'old' symptoms or develop new ones.
- BSc (Hons 2i) University of Leeds 1968
- MB ChB University of Leeds 1971
- MRCP(UK) Royal College of Physicians of London 1974
- MD University of Leeds 1980
- PhD University of Manchester 1987
- FRCP Royal College of Physicians of London 1993
- Fellow of American Gastroenterological Association American Gastroenterological Association 2008
- Senior Research Fellow Yale University School of Medicine 1980
Reference number 1509287
Professional bodies (positions held - last 3 yrs)
- MRCP examiner Royal College of Physicians of London 2019
- Chair, Cardiology Speciality Question Writing Group (for MRCP) Royal College of Physicians of London 2013
- Member, Examination Board for Gastroenterology Specialty Certificate Examination Royal College of Physicians of London 2014
Details of entry to specialist register
- G I Sandle, 1981
Affiliations / memberships
Fellow, American Gastroenterological Association.
Senior Member, Association of Physician of Great Britain & Ireland.
- Spire Leeds Hospital, LS8 1NT
- 14:00 - 17:00
- 0113 218 5908
- Spire Leeds Hospital, LS8 1NT
- 10:00 - 13:00
- 0113 218 5908
- Spire Methley Park Hospital, LS26 9HG
- 10:00 - 13:00
- 01977 664217
Post treatment communication
Following treatment of a Bupa member, I will communicate with GPs in line with Department of Health, GMC and appropriate professional bodies guidelines.
In the event of an urgent query following treatment, Bupa members should use the following contact details
Spire Leeds Hospital 0113-2693939
Spire Methley Park Hospital 01977 518518
or Prof Sandle 07484 301952